Hydrochloric Acid → HCID 66612080, compound

HRID 2204697Notes

Reaction equation

HRID 2204697 reaction equation
[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]([C:31]([N:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)=[O:32])=[CH:9][C:10]([O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[C:11]([CH:22]=2)[C:12]([O:14]CC2C=CC=CC=2)=[O:13])[CH:4]=[N:3]1.[OH-].[Li+].O.Cl>O1CCCC1>[CH3:1][N:2]1[CH:6]=[C:5]([C:7]2[C:8]([C:31]([N:33]3[CH2:38][CH2:37][CH2:36][CH2:35][CH2:34]3)=[O:32])=[CH:9][C:10]([O:23][CH2:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)=[C:11]([CH:22]=2)[C:12]([OH:14])=[O:13])[CH:4]=[N:3]1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 66611035HCID 66611035, compound

Product 1

HCID 66612080HCID 66612080, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of phenylmethyl 5-(1-methyl-1H-pyrazol-4-yl)-2-[(phenylmethyl)oxy]-4-(1-piperidinylcarbonyl)benzoate (may be prepared as described in Description 37; 194 mg, 0.38 mmol) in tetrahydrofuran (4 ml) was added lithium hydroxide (33 mg, 1.38 mmol) and water (1 ml). The solution was stirred for 18 hours then 2M hydrochloric acid (0.69 ml, 1.38 mmol) was added and the solvent removed in vacuo to give the title compound as a gum. 170 mg.

Workup

  1. customthe solvent removed in vacuo

Sources & evidence

ORD record
ord-ee14ce4595f8466dbf333d49b8665800
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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