Hydrochloric Acid → HCID 66611962, compound

HRID 2204700Notes

Reaction equation

HRID 2204700 reaction equation
[CH3:1][N:2]([CH3:35])[C:3]([C:5]1[C:20]([C:21]2[CH:22]=[N:23][N:24]([CH3:26])[CH:25]=2)=[CH:19][C:8]([C:9]([O:11]CC2C=CC=CC=2)=[O:10])=[C:7]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:6]=1)=[O:4].[OH-].[Li+].O.Cl>O1CCCC1>[CH3:1][N:2]([CH3:35])[C:3]([C:5]1[C:20]([C:21]2[CH:22]=[N:23][N:24]([CH3:26])[CH:25]=2)=[CH:19][C:8]([C:9]([OH:11])=[O:10])=[C:7]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:6]=1)=[O:4]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 3939Lithium HydroxideHCID 66611924HCID 66611924, compound

Product 1

HCID 66611962HCID 66611962, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of phenylmethyl 4-[(dimethylamino)carbonyl]-5-(1-methyl-1H-pyrazol-4-yl)-2-[(phenylmethyl)oxy]benzoate (may be prepared as described in Description 40; 195 mg, 0.42 mmol) in tetrahydrofuran (4 ml) was added lithium hydroxide (34 mg, 1.42 mmol) and water (1 ml). The mixture was for 18 hours then 2M hydrochloric acid (0.73 ml, 1.45 mmol) was added. The solvent removed in vacuo to give the title compound as a gum. 154 mg.

Workup

  1. customThe solvent removed in vacuo

Sources & evidence

ORD record
ord-cfd89df397f44e278fef1b341f543b75
Source dataset
uspto-grants-2016_06
Patent number
US09365551B2

Reaction notes

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