反应详情

温度

50 °C

To a suspension of 4-bromo-5-(4-morpholinylmethyl)-2-[(phenylmethyl)oxy]benzoic acid (may be prepared as described in Description 35; 100 mg, 0.25 mmol) in N,N-dimethylformamide (5 ml) was added diisopropylethylamine (0.09 ml, 0.49 mmol), HOBT (45.2 mg, 0.30 mmol), 3-aminopyridine (30.1 mg, 0.32 mmol) and EDC (94 mg, 0.49 mmol). The mixture was heated at 50° C. for 5 hours to allow dissolution. The solvent was removed in vacuo and purified by MDAP to yield the title compound as a white solid. 67 mg.

1. dissolutiondissolution
2. customThe solvent was removed in vacuo
3. custompurified by MDAP