反应详情

To a solution of 6-(tert-butoxycarbonylamino)hexanoic acid (1 eq) in acetone (0.2 M) was added potassium carbonate (2 eq) and (bromomethyl)benzene (2 eq) in acetone (2 M). The reaction mixture was stirred at room temperature for 1 hour. Additional amount of DMF was then added to the reaction mixture to facilitate the dissolution of potassium carbonate. The reaction mixture was stirred at room temperature for another 30 minutes. The mixture was then diluted with ethyl acetate, and washed with 5% citric acid, water and brine. The organic layer was dried over anhydrous Na2SO4, and concentrated en vaccuo. The crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO) using 10-40% EtOAc/Hex to give the product.

1. stirringThe reaction mixture was stirred at room temperature for another 30 minutes
2. washwashed with 5% citric acid, water and brine
3. dry with materialThe organic layer was dried over anhydrous Na2SO4
4. concentrationconcentrated en vaccuo
5. customThe crude mixture was purified by flash chromatography on a COMBIFLASH® system (ISCO)
6. customto give the product