Isopropyl iodide → 3-Iodo-1-isopropyl-1H-pyrazole

3-iodo-1H-pyrazole (250 mg, 1.29 mmol) was added as a solution in DMF (0.8 mL) to a 1.0 M THF solution of NaHMDS (1.5 mL, 1.5 mmol) that had been pre-cooled in an ice water bath. Additional portions of DMF (2×0.35 mL) were used to ensure complete transfer. 2-iodopropane was added in one portion and the reaction mixture was allowed to warm to r.t. After 3.5 h, the reaction mixture was diluted with saturated aqueous NH4Cl (5 mL), water (20 mL), and EtOAc (20 mL). The phases were separated, and the aqueous phase was extracted with EtOAc (20 mL). The combined organic phase was dried over Na2SO4, filtered, and concentrated to afford a crude residue that was purified by silica gel chromatography to provide 3-iodo-1-isopropyl-1H-pyrazole (4.02). LCMS-ESI+ (m/z): [M+H]+ calcd for C6H10IN2: 236.99; found: 236.94.

1. temperaturehad been pre-cooled in an ice water bath
2. customThe phases were separated
3. extractionthe aqueous phase was extracted with EtOAc (20 mL)
4. dry with materialThe combined organic phase was dried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated
7. customto afford a crude residue that
8. customwas purified by silica gel chromatography

ORD record

ord-d220aa48c7a240988ca68724bb16d78f

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09376441B2