反应详情

Benzyl bromide (0.127 mL) was added to a mixture of 4′-(2-hydroxyethoxy)-3′,5′-dimethylbiphenyl-4-carboxylic acid (0.292 g) and potassium carbonate (0.169 g) in N,N-dimethylformamide (5 mL), and the mixture was stirred at room temperature overnight. Water and ethyl acetate were added to the reaction mixture. The organic layer was separated, washed with water and brine, and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/3-1/2) to afford the title compound (0.381 g).

1. customThe organic layer was separated
2. washwashed with water and brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent was evaporated under reduced pressure
5. customthe residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/3-1/2)