Diethyl chlorophosphate → HCID 178483958, compound

HRID 2225545Notes

Reaction equation

HRID 2225545 reaction equation
P(Cl)([O:6][CH2:7][CH3:8])(OCC)=O.Cl.[CH3:11][N:12](NCC(O)=O)[CH3:13].[Cl-].[CH3:20][C@@H:21]1[CH2:26][CH2:25][C@H:24]([NH3+:27])[CH2:23][CH2:22]1>CN(C)C1C=CN=CC=1.C(N(CC)CC)C>[CH3:20][C@@H:21]1[CH2:26][CH2:25][C@H:24]([NH:27][C:7](=[O:6])[CH2:8][N:12]([CH3:13])[CH3:11])[CH2:23][CH2:22]1

Participants

6

Reactant 3

HCID 13139Diethyl chlorophosphateHCID 22931140Dimethylaminoglycine hydrochlorideHCID 178461399HCID 178461399, compound

Product 1

HCID 178483958HCID 178483958, compound

Reagents, catalysts & solvents 2

HCID 142844-(Dimethylamino)pyridineCatalystHCID 8471TriethylamineSolvent

Procedure

Using 6.5 ml of diethyl chlorophosphate, 18 ml of triethylamine, 5.2 g of dimethylaminoglycine hydrochloride, 5 g of cis-4-methylcyclohexylammonium chloride, and 0.15 g of 4-dimethylaminopyridine, a reaction similar to that performed in Example 77 was carried out. As a result, 4.8 g of N-(cis-4-methylcyclohexyl)-2-dimethylaminoacetamide was obtained as a pale yellow oil, which had the following physiochemical properties:

Workup

  1. customa reaction similar to

Sources & evidence

ORD record
ord-ff4c849a5b494635884b3be84fa8c9e8
Source dataset
uspto-grants-1994_09
Patent number
US05344845

Reaction notes

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