反应详情

Triethylamine was added to a suspension of 3-chloro-4-aminophenol hydrochloride (1.80 g, 10.0 mmol) in tetrahydrofuran (200 ml), benzoyl chloride (3.00 ml, 20.0 mmol) was added and the reaction allowed to stir for 18 hours at ambient temperature. The reaction was filtered and the filtrate was evaporated in vacuo. The residue was dissolved in methanol (200 ml), treated with aqueous potassium carbonate solution (0.6 N, 25 ml, 15 mmol) and the mixture stirred for 4 hours at ambient temperature. Addition of saturated aqueous sodium hydrogen carbonate solution (100 ml) caused precipitation of an off-white solid which was collected by suction filtration. Drying in vacuo yielded N-benzoyl 2-chloro-4-hydroxyaniline (2.08 g, 83% yield) as a pale purple solid:

1. additionwas added
2. filtrationThe reaction was filtered
3. customthe filtrate was evaporated in vacuo
4. dissolutionThe residue was dissolved in methanol (200 ml)
5. stirringthe mixture stirred for 4 hours at ambient temperature
6. customprecipitation of an off-white solid which
7. filtrationwas collected by suction filtration
8. customDrying in vacuo