Potassium Carbonate → HCID 86609235, compound

HRID 2233751Notes

Reaction equation

HRID 2233751 reaction equation
[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:16]([F:19])([F:18])[F:17])[CH:14]=3)[NH:9][C:8]=2[CH3:20])=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].Br[CH2:30][C:31]([O:33][CH3:34])=[O:32]>CN(C=O)C>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([O:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:16]([F:19])([F:17])[F:18])[CH:14]=3)[N:9]([CH2:30][C:31]([O:33][CH3:34])=[O:32])[C:8]=2[CH3:20])=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 68628624HCID 68628624, compound

Product 1

HCID 86609235HCID 86609235, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
50 °C

Procedure

A mixture of the product from step (i) (0.60 g), potassium carbonate (0.516 g) and methyl bromoacetate (0.26 ml) in DMF (4 ml) was stirred at 50° C. for 4 h. The reaction was partitioned between ethylacetate/water. The organics were washed with water, dried and evaporated under reduced pressure. The residue was purified by chromatography on silica eluting with 10-20% ethylacetate/iso-hexane. Yield 0.44 g

Workup

  1. customThe reaction was partitioned between ethylacetate/water
  2. washThe organics were washed with water
  3. customdried
  4. customevaporated under reduced pressure
  5. customThe residue was purified by chromatography on silica eluting with 10-20% ethylacetate/iso-hexane

Sources & evidence

ORD record
ord-0e24563f49734a74b13b69eb039734af
Source dataset
uspto-grants-2010_05
Patent number
US07709521B2

Reaction notes

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