Triethylamine → HCID 86609239, compound

HRID 2233760Notes

Reaction equation

HRID 2233760 reaction equation
[Cl:1][C:2]1[CH:27]=[CH:26][C:5]([O:6][C:7]2[C:15]3[C:10](=[CH:11][CH:12]=[CH:13][C:14]=3[N+:16]([O-])=O)[N:9]([CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21])[C:8]=2[CH3:25])=[CH:4][CH:3]=1.C(N(CC)CC)C>CCOC(C)=O.[Pt]>[NH2:16][C:14]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:15]=1[C:7]([O:6][C:5]1[CH:26]=[CH:27][C:2]([Cl:1])=[CH:3][CH:4]=1)=[C:8]([CH3:25])[N:9]2[CH2:19][C:20]([O:22][CH2:23][CH3:24])=[O:21]

Participants

5

Reactant 2

HCID 8471TriethylamineHCID 86609238HCID 86609238, compound

Product 1

HCID 86609239HCID 86609239, compound

Reagents, catalysts & solvents 2

HCID 23939PlatinumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

The product from step (iii) (1.0 g) was dissolved in EtOAc (20 ml), triethylamine (1.1 ml) added, followed by 5% Pt/C (50 mg) and hydrogenated at 1 atm and RT for 6 h. The catalyst was filtered off and the filtrate evaporated to give a light brown solid. Yield 800 mg.

Workup

  1. filtrationThe catalyst was filtered off
  2. customthe filtrate evaporated
  3. customto give a light brown solid

Sources & evidence

ORD record
ord-127cb798290d47ef8bf1eff458003817
Source dataset
uspto-grants-2010_05
Patent number
US07709521B2

Reaction notes

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