反应详情

POCl3 (3.3 ml, 35.67 mmol) was added to 1,2-dichloroethane (4 ml), then anhydrous DMF (2.75 ml, 35.67 mmol) was added very slowly. The mixture was stirred at room temperature for ˜10 minutes. 5-Ethyl-1H-pyrrole-3-carbonitrile (Intermediate 30, 856 mg, 7.13 mmol) in 1,2-dichloroethane (2 ml) was added dropwise and the mixture was heated at 80° C. for ˜30 minutes. The mixture was cooled to room temperature and sodium acetate (2.5 g/5 ml) was added and the mixture was stirred for 1 h. The brown/black emulsion was extracted with DCM (4×50 ml). The combined organic phase was washed with water (2×50 ml) dried over Na2SO4 and concentrated in vacuo to give the title compound. (819 mg).

1. temperaturethe mixture was heated at 80° C. for ˜30 minutes
2. temperatureThe mixture was cooled to room temperature
3. stirringthe mixture was stirred for 1 h
4. extractionThe brown/black emulsion was extracted with DCM (4×50 ml)
5. washThe combined organic phase was washed with water (2×50 ml)
6. dry with materialdried over Na2SO4
7. concentrationconcentrated in vacuo