Triethylamine → HCID 68582884, compound

HRID 2240629Notes

Reaction equation

HRID 2240629 reaction equation
[O:1]=[C:2]1[N:8]([CH2:9][CH2:10][CH2:11][C:12]([OH:14])=O)[C:7]2[CH:15]=[CH:16][CH:17]=[CH:18][C:6]=2[C:5](=[O:19])[CH2:4][CH2:3]1.[CH2:20]([N:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)[CH3:21].CCN=C=NCCCN(C)C.Cl.CCN(CC)CC>O1CCCC1>[CH2:20]([N:22]1[CH2:27][CH2:26][N:25]([C:12](=[O:14])[CH2:11][CH2:10][CH2:9][N:8]2[C:2](=[O:1])[CH2:3][CH2:4][C:5](=[O:19])[C:6]3[CH:18]=[CH:17][CH:16]=[CH:15][C:7]2=3)[CH2:24][CH2:23]1)[CH3:21]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 791961-EthylpiperazineHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 68583274HCID 68583274, compound

Product 1

HCID 68582884HCID 68582884, compoundYield 12.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

On the basis of the method described by M. K. Dhaon et al. in J. Org. Chem. 47 (1982) p. 1962, reaction of 4-(2,5-dioxo-2,3,4,5-tetrahydrobenzo[b]azepin-1-yl)butanoic acid (0.06 g) from step b and 1-ethylpiperazine (0.25 mmol, 0.03 g) in the presence of EDC.HCl (N′-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride) (0.36 mmol, 0.07 g), Et3N (0.48 mmol, 0.05 g) in tetrahydrofuran (5 ml) afforded 10.0 mg of the title compound.

Sources & evidence

ORD record
ord-f1aac693772f4d848cb288b4ca96e1b2
Source dataset
uspto-grants-2010_05
Patent number
US07723384B2

Reaction notes

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