3-Aminobenzoic Acid → HCID 10423016, compound

HRID 2248520Notes

Reaction equation

HRID 2248520 reaction equation
[C:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)#[N:2].ClC1N=C(OC)N=C(OC)N=1.CN1CCOCC1.[NH2:30][C:31]1[CH:32]=[C:33]([CH:37]=[CH:38][CH:39]=1)[C:34]([OH:36])=[O:35]>CN(C=O)C.C(Cl)Cl>[C:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:30][C:31]2[CH:32]=[C:33]([CH:37]=[CH:38][CH:39]=2)[C:34]([OH:36])=[O:35])=[O:9])=[CH:10][CH:11]=1)#[N:2]

Participants

6

Reactant 4

HCID 74193-Aminobenzoic AcidHCID 79724-MethylmorpholineHCID 120874-Cyanobenzoic acidHCID 184502-Chloro-4,6-dimethoxy-1,3,5-triazine

Product 1

HCID 10423016HCID 10423016, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 22350042dichloromethane N,N-dimethylformamideSolvent

Procedure

4-Cyanobenzoic acid is activated with 2-chloro-4,6-dimethoxy-1,3,5-triazine and N-methylmorpholine analogously to Example 1 and subsequently reacted with 3-aminobenzoic acid in DMF/CH2Cl2. There is obtained m-(p-cyanobenzamido)benzoic acid in the form of colourless crystals. Yield: 70%, m.p. 267° C. (ethyl acetate/acetonitrile).

Sources & evidence

ORD record
ord-4a871c865f0f4bdb9e83fb4acfc81f51
Source dataset
uspto-grants-1991_08
Patent number
US05039805

Reaction notes

Loading…