反应详情

温度

100 °C

In 31 ml of N,N-dimethylformamide are suspended 3.1 g of 3-hydroxy-4-isobutoxybenzaldehyde, 0.7 g of 60% sodium hydride and 3 ml of acetic anhydride. The suspension is stirred for 2 hours at 100° C. The reaction mixture is added to a mixture of ethyl acetate and water, pH is adjusted to 2 with 6 mol/L hydrochloric acid, and the organic layer is separated. The organic layer thus obtained is washed with water and saturated aqueous solution of sodium chloride successively and dried over anhydrous magnesium sulfate, and then the solvent is distilled off under reduced pressure. Thus, 4.2 g of 5-formyl-2-isobutoxyphenyl acetate is obtained as a yellow oily product.

1. customthe organic layer is separated
2. customThe organic layer thus obtained
3. washis washed with water and saturated aqueous solution of sodium chloride successively
4. dry with materialdried over anhydrous magnesium sulfate
5. distillationthe solvent is distilled off under reduced pressure