2-Bromopropane → HCID 56630726, compound

HRID 2259560Notes

Reaction equation

HRID 2259560 reaction equation
[NH:1]1[C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4][N:3]=[N:2]1.C(=O)([O-])[O-].[K+].[K+].[CH:23](Br)([CH3:25])[CH3:24]>CN(C)C=O>[CH:23]([N:3]1[N:2]=[N:1][C:5]([C:6]2[C:11](=[O:12])[N:10]3[CH:13]=[CH:14][CH:15]=[CH:16][C:9]3=[N:8][CH:7]=2)=[N:4]1)([CH3:25])[CH3:24]

Participants

5

Reactant 3

HCID 63582-BromopropaneHCID 11430Potassium CarbonateHCID 178515422HCID 178515422, compound

Product 1

HCID 56630726HCID 56630726, compoundYield 55.8%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 0.9 g (0.0042 moles) of 3-(1H-tetrazol-5-yl)-4-oxo-4H-pyrido[1,2-a]pyrimidine, 25 ml of dimethylformamide, 1.15 g (0.0084 moles) of anhydrous potassium carbonate and 1.1 ml (0.0126 moles) of isopropyl bromide was stirred at 90° C. for 1 hour. The hot yellow solution was filtered, the filtrate evaporated. To the crystalline residue 25 ml of water was added, and the crystals were collected. 0.6 g (55.8%) of the title compound was obtained, in the form of white crystals, m.p.: 146°-148° C.

Workup

  1. filtrationThe hot yellow solution was filtered
  2. customthe filtrate evaporated
  3. additionTo the crystalline residue 25 ml of water was added
  4. customthe crystals were collected

Sources & evidence

ORD record
ord-e5f4d57f8fac49309363d2511fa8c3ba
Source dataset
uspto-grants-1995_12
Patent number
US05475000

Reaction notes

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