反应详情

温度

160 °C

159 (500 mg, 1.6 mmol), 2,6-Dichloro-pyridine (360 mg, 24 mmol) are dissolved in 15 ml of dimethylformamide. After addition of potassium carbonate (340 mg, 24 mmol) and a catalytic amount Cu-powder the mixture is heated to 160° C. for 3 hours. The reaction mixture is cooled to room temperature, diluted with ethyl acetate and washed with water. The organic layers are dried over sodium sulphate and evaporated. The crude product is solved in dichloromethane and after evaporation crystallized with cyclohexane.

1. temperatureThe reaction mixture is cooled to room temperature
2. washwashed with water
3. dry with materialThe organic layers are dried over sodium sulphate
4. customevaporated
5. customafter evaporation
6. customcrystallized with cyclohexane