反应详情

A DMF (100 ml) suspension of 4-hydroxyphenylacetic acid (10.0 g, 55.5 mmols), benzyl bromide (7.93 ml, 66.6 mmols) and potassium carbonate (23.1 g, 167 mmols) was stirred at room temperature for 6 hours. Water was added to the reaction mixture, which was then extracted with ethyl acetate. The organic layer was washed with water and a saturated aqueous sodium chloride solution, and then dried. The solvent was evaporated out in vacuo, and the resulting crude product was purified by silica gel column chromatography (hexane alone to hexane:ethyl acetate=10:1) to obtain the entitled compound (14.6 g) as an oil.

1. extractionwas then extracted with ethyl acetate
2. washThe organic layer was washed with water
3. dry with materiala saturated aqueous sodium chloride solution, and then dried
4. customThe solvent was evaporated out in vacuo
5. customthe resulting crude product was purified by silica gel column chromatography (hexane alone to hexane