反应详情

To the mixed solution of 2-oxo-1,2,3,4-tetrahydro-3-quinolineacetic acid (810 mg) in THF (10 ml) and acetonitrile (10 ml), WSC (1.15 g), HOBt (610 mg), dimethylamine hydrochloride (650 mg) and triethylamine (1.67 ml) were added subsequently, which was stirred at room temperature overnight. Water was added to the reaction mixture, which was extracted with a mixed solvent of ethyl acetate-THF (1:1). The organic layer was washed subsequently with 0.1N aqueous hydrochloric acid solution, a saturated aqueous sodium bicarbonate solution, and a saturated aqueous sodium chloride solution, then dried and concentrated to obtain the entitled compound (620 mg).

1. extractionwas extracted with a mixed solvent of ethyl acetate-THF (1:1)
2. washThe organic layer was washed subsequently with 0.1N aqueous hydrochloric acid solution
3. dry with materiala saturated aqueous sodium bicarbonate solution, and a saturated aqueous sodium chloride solution, then dried
4. concentrationconcentrated