Hydrogen Bromide → 6,8-Dibromoimidazo[1,2-a]pyrazine

Temperature

40 °C

A 1-L four-neck round bottom flask equipped with a temperature probe, mechanical stirrer and reflux condenser was charged with 2-bromo-1,1-diethoxyethane (68.1 g, 346 mmol) and 48% aqueous hydrogen bromide (11.3 mL, 99.2 mmol), and the reaction mixture was stirred at reflux for 2 h. The resulting mixture was allowed to cool to 40° C. and solid sodium bicarbonate (8.50 g, 101 mmol) was added in small portions until gas evolution was observed to cease. Caution: initial addition of sodium bicarbonate to the warm solution resulted in vigorous gas evolution (foaming). The resulting suspension was filtered into a 1-L four-neck round bottomed flask and the filter cake was washed with ethanol (200 mL). The flask was equipped with a temperature probe, mechanical stirrer and reflux condenser. 3,5-Dibromopyrazin-2-amine (50.0 g, 198 mmol) was added and the reaction mixture was heated at reflux, with vigorous stirring, for 16 h. After this time, the suspension was cooled to 0° C. and filtered. The filter cake was washed with cold ethanol (50 mL), dried under vacuum and added to a 1-L three-neck round bottomed flask equipped with a mechanical stirrer. Water (200 mL) was added and the vigorously stirred suspension was treated portion-wise with solid potassium carbonate (27.4 g, 198 mmol). Caution: gas evolution upon the addition of potassium carbonate observed. After stirring for 30 min, the resulting precipitate was isolated by filtration and the filter cake washed with water (100 mL) followed by ethanol (50 mL). The filter cake was dried at 50° C. to a constant weight, under vacuum to provide 6,8-dibromoimidazo[1,2-a]pyrazine (1) (52.0 g, 94%) as a light yellow solid: 1H NMR (300 MHz, DMSO-d6) δ 9.02 (s, 1H), 8.23 (s, 1H), 7.90 (s, 1H).

1. customA 1-L four-neck round bottom flask equipped with a temperature probe, mechanical stirrer
2. temperaturereflux condenser
3. temperatureat reflux for 2 h
4. customresulted in vigorous gas evolution (foaming)
5. filtrationThe resulting suspension was filtered into a 1-L four-neck round bottomed flask
6. washthe filter cake was washed with ethanol (200 mL)
7. customThe flask was equipped with a temperature probe, mechanical stirrer
8. temperaturereflux condenser
9. temperaturethe reaction mixture was heated
10. temperatureat reflux, with vigorous stirring, for 16 h
11. temperatureAfter this time, the suspension was cooled to 0° C.
12. filtrationfiltered
13. washThe filter cake was washed with cold ethanol (50 mL)
14. customdried under vacuum
15. additionadded to a 1-L three-neck round bottomed flask
16. customequipped with a mechanical stirrer
17. additionWater (200 mL) was added
18. stirringAfter stirring for 30 min
19. customthe resulting precipitate was isolated by filtration
20. washthe filter cake washed with water (100 mL)
21. customThe filter cake was dried at 50° C. to a constant weight, under vacuum

ORD record

ord-2b84a3fc04e941f7bee319e5a2fedc4c

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09120811B2