反应详情

温度

80 °C

To a solution of 2-(3-bromobenzenesulfonylamino)-5-methyl-benzensulfonamide (1.50 g, 3.70 mmol), 3,4-dichlorobenzeneboronic acid (0.84 g, 4.44 mmol), tricyclohexyl phosphine (0.45 g, 1.60 mmol) and potassium phosphate (3 g, 14.15 mmol) in DMF (10 mL), was added Pd(OAc)2 (0.17 g, 0.74 mmol). The reaction mixture was stirred at 80° C. for 10 h, diluted with 1N HCl and the product was extracted with ethyl acetate. The organic phase was separated, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by flash column chromatography using ethyl acetate/hexane (1:3) to afford the title compound (0.9 g, 51%).

1. extractionthe product was extracted with ethyl acetate
2. customThe organic phase was separated
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated in vacuo
5. customThe crude product was purified by flash column chromatography