Hydrochloric Acid → HCID 86754565, compound

HRID 2286832Notes

Reaction equation

HRID 2286832 reaction equation
[NH2:1][C@H:2]([C:5]([OH:7])=[O:6])[CH2:3][SH:4].[CH2:8](O)[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17].[ClH:19]>C(OCC)(=O)C>[ClH:19].[CH2:8]([O:6][C:5](=[O:7])[C@H:2]([CH2:3][SH:4])[NH2:1])[CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH3:17]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 5862L-(+)-CysteineHCID 81741-Decanol

Product 1

HCID 86754565HCID 86754565, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
150 °C

Procedure

L-Cysteine (157.4 g) was added to 250 ml of decyl alcohol saturated with dry HCl. The mixture was heated to 150° C. for 6 hours. The solution was cooled and was mixed with an equal volume of ethyl acetate. The solution was cooled in a dry ice bath to give crystals. The crystals were filtered and were then recrystallized from ethyl acetate, mp 96°-99° C., yield 100 g, IR (KBr) 1745 cm-1.

Workup

  1. temperatureThe solution was cooled
  2. temperatureThe solution was cooled in a dry ice bath
  3. customto give crystals
  4. filtrationThe crystals were filtered
  5. customwere then recrystallized from ethyl acetate, mp 96°-99° C., yield 100 g, IR (KBr) 1745 cm-1

Sources & evidence

ORD record
ord-5441f168e1134cddb9a9c2a99401cd95
Source dataset
uspto-grants-1981_05
Patent number
US04268441

Reaction notes

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