Acetone → HCID 54041279, compound

HRID 2288569Notes

Reaction equation

HRID 2288569 reaction equation
C([N:3](CC)CC)C.[CH3:8][C:9]([CH3:11])=[O:10].CO[C:14]1C=[CH:18][CH:17]=[CH:16][C:15]=1O.[C:21](Cl)(=[O:25])[C:22]([CH3:24])=[CH2:23]>O>[C:9]([C:11]1[CH:18]=[CH:17][C:16]([CH:23]=[C:22]([CH3:24])[C:21]([NH2:3])=[O:25])=[CH:15][CH:14]=1)(=[O:10])[CH3:8]

Participants

6

Reactant 4

HCID 180AcetoneHCID 460GuaiacolHCID 8471TriethylamineHCID 13528Methacryloyl chloride

Product 1

HCID 54041279HCID 54041279, compoundYield 78%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Into a four-necked flask equipped with an agitator, a reflux condenser, a thermometer and a dropping apparatus were charged 135 g of (4-amino)acetophenone, 101 g of triethylamine, 500 ml of acetone and 0.5 g of methoxyphenol. To the reaction mixture was then added dropwise 105 g of methacryloyl chloride at a temperature of 10° C. in 2 hours. To the reaction solution was then added 1 l of distilled water. The resulting crystal was recovered by filtration. (Yield: 78%)

Workup

  1. customInto a four-necked flask equipped with an agitator, a reflux condenser
  2. filtrationThe resulting crystal was recovered by filtration

Sources & evidence

ORD record
ord-628ba346d45145ff890a525bd12756f5
Source dataset
uspto-grants-2000_07
Patent number
US06090531

Reaction notes

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