反应详情

Monomethyl adipate (61 g, 350 mmol) was treated with excess oxalyl chloride in tetrahydrofuran. The mixture was concentrated, and the resulting acid chloride was mixed with 2,6-Diisopropyl phenol (57 g, 350 mmol) at 0° C. Aluminum chloride (93 g, 700 mmol) and a catalytic amount of 1,2-dichloroethane were added in portions, and the mixture was allowed to warm to room temperature and stirred overnight. The reaction was quenched with 1 M HCl and extracted with ethyl acetate. Concentrated in vacuo and chromatographed the residue to give the expected product.

1. concentrationThe mixture was concentrated
2. customThe reaction was quenched with 1 M HCl
3. extractionextracted with ethyl acetate
4. concentrationConcentrated in vacuo
5. customchromatographed the residue