反应详情

(S)-3,3-dimethyl-2-hydroxybutyric acid (2.1 grams, 15.9 mmol) and triethylamine (3.3 mL, 23.8 mmoL) were dissolved in 15 mL DMF. Benzylbromide (2.8 mL, 23.8 mmol) was added and the mixture was stirred overnight. Ethyl acetate was added and the mixture was washed with water (3×) and sat'd NaCl then dried over sodium sulfate and concentrated. Flash chromatography (150 g silica, 7/1Hexane/EtOAc) afforded 3.4 grams (96%) of the title compound. 1H NMR (300 MHz, CDCl3). δ 0.98 (s, 9H), 2.75 (d, 1H), 3.85 (d, 1H), 5.23, (s, 2H), 7.27-7.3 (m, 5H).

1. washthe mixture was washed with water (3×)
2. dry with materialthen dried over sodium sulfate
3. concentrationconcentrated