Triphenylphosphine → 1-Aminoisoquinoline-7-carbonitrile

HRID 2304299Notes

Reaction equation

HRID 2304299 reaction equation
[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9](OS(C(F)(F)F)(=O)=O)[CH:10]=2)[CH:5]=[CH:4][N:3]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.[CH3:39][N:40]1CCCC1=O>C([O-])(=O)C.[Pd+2].C([O-])(=O)C.[C-]#N.[Zn+2].[C-]#N>[NH2:1][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[C:9]([C:39]#[N:40])[CH:10]=2)[CH:5]=[CH:4][N:3]=1

Participants

6

Reactant 3

HCID 11776TriphenylphosphineHCID 13387N-methyl-2-pyrrolidoneHCID 54109345Trifluoromethanesulfonic acid 1-amino-isoquinolin-7-yl ester

Product 1

HCID 226658481-Aminoisoquinoline-7-carbonitrileYield 94%

Reagents, catalysts & solvents 2

HCID 11186Zinc cyanide (Zn(CN)2)CatalystHCID 167845palladium(II) acetateCatalyst

Procedure

Palladium acetate (0.9 g) was added to a heated mixture of trifluoromethanesulfonic acid 1-amino-isoquinolin-7-yl ester (5.8 g), zinc cyanide (2.3 g) and triphenylphosphine (1.0 g) in 75 mL of N-methyl-pyrrolidone at 190° C. (exothermic!). Stirring was continued at 190° C. for 2 h. Precipitated material was removed by filtration and discarded. Ethyl acetate was added and the organic mixture washed with 2N aqueous ammonia, water and brine and dried (Na2SO4). Filtration and concentration afforded a brownish oil, which was purified by silica chromatography (ethyl acetate/isohexane=3/7, 4/6, 5/5, 6/4, 7/3, 8/2) to give 3.2 g (94%) of the title compound as yellow crystals. M.p. 183-186° C.

Workup

  1. customPrecipitated material was removed by filtration
  2. additionEthyl acetate was added
  3. washthe organic mixture washed with 2N aqueous ammonia, water and brine
  4. dry with materialdried (Na2SO4)
  5. filtrationFiltration and concentration
  6. customafforded a brownish oil, which
  7. customwas purified by silica chromatography (ethyl acetate/isohexane=3/7, 4/6, 5/5, 6/4, 7/3, 8/2)

Sources & evidence

ORD record
ord-e8b25f37b5cf4a5697a2ee62435be8a3
Source dataset
uspto-grants-2002_08
Patent number
US06432955B1

Reaction notes

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