反应详情

Mixture of (S)-1-[3-(2-methyl-morpholin-4-yl)-phenyl]-ethylamine hydrochloric acid salt, Preparation 41(30 mg, 0.10 mmol), cinnamic acid (17 mg, 0.11 mmol), EDC (40 mg, 0.20 mmol), DMAP (13 mg, 0.10 mmol), triethylamine (0.06 ml, 0.40 mmol) in dichloromethane (0.5 mL) was stirred at room temperature overnight. The reaction mixture was purified by filtering through 2 g silica-gel syringe with 70% ethyl acetate/hexanes. The filtrate was concentrated under vacuum to provide the title compound as a yellow solid.

1. customThe reaction mixture was purified
2. filtrationby filtering through 2 g silica-gel syringe with 70% ethyl acetate/hexanes
3. concentrationThe filtrate was concentrated under vacuum