Water → HCID 67136322, compound

HRID 230876Notes

Reaction equation

HRID 230876 reaction equation
[OH:1][C:2]1[CH:17]=[C:16]([OH:18])[C:5]([C:6](=[O:15])[CH:7]=[CH:8][CH:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH2:10]2)=[C:4]([O:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:31](Br)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1.O>CN(C)C=O>[CH2:31]([O:1][C:2]1[CH:17]=[C:16]([OH:18])[C:5]([C:6](=[O:15])[CH:7]=[CH:8][CH:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH2:14]2)=[C:4]([O:19][CH2:20][C:21]([O:23][CH3:24])=[O:22])[CH:3]=1)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1

Participants

6

Reactant 4

HCID 962WaterHCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 67135797HCID 67135797, compound

Product 1

HCID 67136322HCID 67136322, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 4′,6′-dihydroxy-2′-(methoxycarbonylmethoxy)dihydrochalcone (0.6 g) in N,N-dimethylformamide (10 mL) were added potassium carbonate (0.26 g) and benzyl bromide (0.22 mL), and the mixture was stirred at room temperature for 3 days. The reaction mixture was poured into water, and the precipitated crystals were collected by filtration and dried under reduced pressure to give the title compound (0.53 g).

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. customdried under reduced pressure

Sources & evidence

ORD record
ord-98a75bf40fb341b28759c5935a5b86ad
Source dataset
uspto-grants-2009_07
Patent number
US07566699B2

Reaction notes

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