Hydrochloric Acid → 6-(4-Bromo-2-chloro-phenylamino)-7-fluoro-3-(tetrahydro-pyran-2-ylmethyl)-3H-benzoimidazole-5-carboxylic acid
Reaction equation
[C:46]([O:47][CH2:48][CH3:49])(=[O:50])[CH3:51].[CH3:1][O:2][C:3](=[O:4])[c:5]1[cH:6][c:7]2[c:8]([n:9][cH:10][n:11]2[CH2:12][CH:13]2[O:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[c:19]([F:30])[c:20]1[NH:21][c:22]1[c:23]([Cl:29])[cH:24][c:25]([Br:28])[cH:26][cH:27]1.[ClH:40].[Li+:38].[O:32]1[CH2:33][CH2:34][CH2:35][CH2:36]1.[O:41]1[CH2:42][CH2:43][CH2:44][CH2:45]1.[OH-:37].[OH2:31].[OH2:39]>>[O:2]=[C:3]([OH:4])[c:5]1[cH:6][c:7]2[c:8]([n:9][cH:10][n:11]2[CH2:12][CH:13]2[O:14][CH2:15][CH2:16][CH2:17][CH2:18]2)[c:19]([F:30])[c:20]1[NH:21][c:22]1[c:23]([Cl:29])[cH:24][c:25]([Br:28])[cH:26][cH:27]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-d2466b21eb624669a45ab9317038b4df
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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