Hydrochloric Acid → Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate

HRID 2313191Notes

Reaction equation

HRID 2313191 reaction equation
[C:12]([n:13]1[cH:14][cH:15][n:16][cH:17]1)([n:18]1[cH:19][cH:20][n:21][cH:22]1)=[O:23].[C:25]([CH2:26][C:27]([O-:28])=[O:29])(=[O:30])[O:31][CH2:32][CH3:33].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[ClH:34].[F:1][c:2]1[c:3]([C:4](=[O:5])[OH:6])[cH:7][cH:8][c:9]([F:11])[cH:10]1.[Mg+:24].[O:35]1[CH2:36][CH2:37][CH2:38][CH2:39]1.[OH2:40]>>[F:1][c:2]1[c:3]([C:4](=[O:6])[CH2:26][C:25](=[O:30])[O:31][CH2:32][CH3:33])[cH:7][cH:8][c:9]([F:11])[cH:10]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 962WaterHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 682631,1'-CarbonyldiimidazoleHCID 741022,4-Difluorobenzoic acidHCID 3595298Propanedioic acid, monoethyl esterHCID 178506988HCID 178506988, compound

Product 1

HCID 2758338Ethyl 3-(2,4-difluorophenyl)-3-oxopropanoate

Sources & evidence

ORD record
ord-8ea949144b6941c4a7af135f3ebc2b7a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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