反应详情

A solution of 17 g of 3-methylcyclohexanecarbonitrile in 140 ml of THF has added to it, at -78°, a lithium diisopropylamide solution (prepared from 140 ml of THF, 16 g of diisopropylamine and 100 ml of 1.6-molar butyllithium solution in hexane), followed, after 2 hours, by 25 g of diethyl carbonate, and stirring is continued for one hour. After heating to room temperature and pouring onto 300 ml of ice-water the mixture is neutralized with dilute hydrochloric acid. Customary working up and distillation gives ethyl 3-methyl-1-cyanocyclohexanecarboxylate.

1. distillationdistillation