Water → (2-Trimethylsilanylethynyl-pyridin-3-yl)carbamic acid ethyl ester

HRID 2315116Notes

Reaction equation

HRID 2315116 reaction equation
[CH2:1]([CH3:2])[O:3][C:4]([NH:5][c:6]1[c:7]([Br:12])[n:8][cH:9][cH:10][cH:11]1)=[O:13].[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[CH3:21][Si:22]([CH3:23])([CH3:24])[C:25]#[CH:26].[Cu:68][I:69].[OH2:70].[Pd:27]([Cl:28])[Cl:29].[c:30]1([P:31]([c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[c:38]2[cH:39][cH:40][cH:41][cH:42][cH:43]2)[cH:44][cH:45][cH:46][cH:47][cH:48]1.[c:49]1([P:50]([c:51]2[cH:52][cH:53][cH:54][cH:55][cH:56]2)[c:57]2[cH:58][cH:59][cH:60][cH:61][cH:62]2)[cH:63][cH:64][cH:65][cH:66][cH:67]1>>[CH2:1]([CH3:2])[O:3][C:4]([NH:5][c:6]1[c:7]([C:26]#[C:25][Si:22]([CH3:21])([CH3:23])[CH3:24])[n:8][cH:9][cH:10][cH:11]1)=[O:13]

Participants

8

Reactant 7

HCID 962WaterHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 13803673(2-Bromo-pyridin-3-yl)carbamic acid ethyl ester

Product 1

HCID 58875356(2-Trimethylsilanylethynyl-pyridin-3-yl)carbamic acid ethyl ester

Sources & evidence

ORD record
ord-5edb2f17e46e408e8183344b546e93b1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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