Dimethylformamide → Hydrochloric Acid

HRID 2323586Notes

Reaction equation

HRID 2323586 reaction equation
[CH3:25][O:26][CH2:27][C:28]([C:29]#[CH:30])([OH:31])[CH3:32].[CH3:33][N:34]([CH3:35])[CH:36]=[O:37].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[Cu:45][I:46].[NH2:1][c:2]1[n:3]([CH2:18][c:19]2[n:20][cH:21][cH:22][cH:23][cH:24]2)[c:4]2[n:5][c:6]([Cl:17])[cH:7][cH:8][c:9]2[c:10](=[O:16])[c:11]1[C:12](=[O:13])[NH:14][CH3:15]>>[ClH:17].[NH2:1][c:2]1[n:3]([CH2:18][c:19]2[n:20][cH:21][cH:22][cH:23][cH:24]2)[c:4]2[n:5][c:6]([C:30]#[C:29][C:28]([CH2:27][O:26][CH3:25])([OH:31])[CH3:32])[cH:7][cH:8][c:9]2[c:10](=[O:16])[c:11]1[C:12](=[O:13])[NH:14][CH3:15]

Participants

7

Reactant 5

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 217064261-Methoxy-2-methylbut-3-yn-2-olHCID 866423382-Amino-7-chloro-N-methyl-4-oxo-1-(pyridin-2-ylmethyl)-1,4-dihydro-1,8-naphthyridine-3-carboxamide

Product 2

HCID 313Hydrochloric AcidHCID 670817742-amino-7-(3-hydroxy-4-methoxy-3-methyl-but-1-ynyl)-N-methyl-4-oxo-1-(2-pyridylmethyl)-1,8-naphthyridine-3-carboxamide

Sources & evidence

ORD record
ord-f2b6ad95a2a34453a32eb71aa1e66a97
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…