Tetrahydrofuran → Benzyl [4-(4-iodophenyl)but-3-yn-1-yl]carbamate

HRID 2326987Notes

Reaction equation

HRID 2326987 reaction equation
[CH2:16]([c:17]1[cH:18][cH:19][cH:20][cH:21][cH:22]1)[O:23][C:24]([NH:25][CH2:26][CH2:27][C:28]#[CH:29])=[O:30].[CH2:31]1[O:32][CH2:33][CH2:34][CH2:35]1.[CH3:1][CH2:2][N:3]([CH2:4][CH3:5])[CH2:6][CH3:7].[Cu:36][I:37].[I:8][c:9]1[cH:10][cH:11][c:12]([I:15])[cH:13][cH:14]1.[Pd:38]([Cl:39])[Cl:40].[c:41]1([P:42]([c:43]2[cH:44][cH:45][cH:46][cH:47][cH:48]2)[c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[cH:55][cH:56][cH:57][cH:58][cH:59]1.[c:60]1([P:61]([c:62]2[cH:63][cH:64][cH:65][cH:66][cH:67]2)[c:68]2[cH:69][cH:70][cH:71][cH:72][cH:73]2)[cH:74][cH:75][cH:76][cH:77][cH:78]1>>[c:9]1([C:29]#[C:28][CH2:27][CH2:26][NH:25][C:24]([O:23][CH2:16][c:17]2[cH:18][cH:19][cH:20][cH:21][cH:22]2)=[O:30])[cH:10][cH:11][c:12]([I:15])[cH:13][cH:14]1

Participants

8

Reactant 7

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 12208p-DiiodobenzeneHCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 21185506HCID 21185506, compound

Product 1

HCID 59750570Benzyl [4-(4-iodophenyl)but-3-yn-1-yl]carbamate

Sources & evidence

ORD record
ord-849030bf8578426783b565aa8c0226e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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