Acetate → Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

HRID 2328974Notes

Reaction equation

HRID 2328974 reaction equation
[Br:1][c:2]1[cH:3][c:4]([F:10])[c:5]([OH:9])[c:6]([F:8])[cH:7]1.[C:18]([CH:19]=[CH2:20])(=[O:21])[O:22][CH2:23][CH3:24].[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17].[CH3:39][CH2:40][O:41][C:42]([CH3:43])=[O:44].[O-:31][C:32]([CH3:33])=[O:34].[O-:35][C:36]([CH3:37])=[O:38].[O:25]=[CH:26][N:27]([CH3:28])[CH3:29].[Pd+2:30]>>[c:2]1([CH2:20][CH2:19][C:18](=[O:21])[O:22][CH2:23][CH3:24])[cH:3][c:4]([F:10])[c:5]([OH:9])[c:6]([F:8])[cH:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 8857Ethyl AcetateHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27362924-Bromo-2,6-difluorophenol

Product 1

HCID 23136305Ethyl 3-(3,5-difluoro-4-hydroxyphenyl)propanoate

Sources & evidence

ORD record
ord-30afb0799db24f45a16b9c9ea4c76363
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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