1,2-Dimethoxyethane → Methyl 2-(4-fluoro-2-((trimethylsilyl)ethynyl)phenyl)acetate

HRID 2332687Notes

Reaction equation

HRID 2332687 reaction equation
[CH3:14][CH2:15][N:16]([CH2:17][CH3:18])[CH2:19][CH3:20].[CH3:21][Si:22]([CH3:23])([CH3:24])[C:25]#[CH:26].[CH3:27][O:28][CH2:29][CH2:30][O:31][CH3:32].[Cu:33][I:34].[F:1][c:2]1[cH:3][c:4]([I:13])[c:5]([CH2:8][C:9](=[O:10])[O:11][CH3:12])[cH:6][cH:7]1.[Pd:35]([Cl:36])[Cl:37].[c:38]1([P:39]([c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[c:46]2[cH:47][cH:48][cH:49][cH:50][cH:51]2)[cH:52][cH:53][cH:54][cH:55][cH:56]1.[c:57]1([P:58]([c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[c:65]2[cH:66][cH:67][cH:68][cH:69][cH:70]2)[cH:71][cH:72][cH:73][cH:74][cH:75]1>>[F:1][c:2]1[cH:3][c:4]([C:26]#[C:25][Si:22]([CH3:21])([CH3:23])[CH3:24])[c:5]([CH2:8][C:9](=[O:10])[O:11][CH3:12])[cH:6][cH:7]1

Participants

8

Reactant 7

HCID 80711,2-DimethoxyethaneHCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 59457703Methyl 2-(4-fluoro-2-iodophenyl)acetate

Product 1

HCID 59457720Methyl 2-(4-fluoro-2-((trimethylsilyl)ethynyl)phenyl)acetate

Sources & evidence

ORD record
ord-51f14350de1c42369cc212a7bd4ea6f7
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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