Acetate → Ethyl 3-(5-hydroxypyridin-2-yl)prop-2-enoate

HRID 2338461Notes

Reaction equation

HRID 2338461 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([OH:8])[cH:6][n:7]1.[C:50]([O-:51])(=[O:52])[CH3:53].[C:55]([O-:56])(=[O:57])[CH3:58].[C:9]([CH:10]=[CH2:11])(=[O:12])[O:13][CH2:14][CH3:15].[CH3:38][CH2:39][N:40]([CH2:41][CH3:42])[CH2:43][CH3:44].[CH3:45][N:46]([CH3:47])[CH:48]=[O:49].[Pd+2:54].[c:16]1([CH3:17])[cH:18][cH:19][cH:20][cH:21][c:22]1[P:23]([c:24]1[cH:25][cH:26][cH:27][cH:28][c:29]1[CH3:30])[c:31]1[cH:32][cH:33][cH:34][cH:35][c:36]1[CH3:37]>>[c:2]1([CH:11]=[CH:10][C:9](=[O:12])[O:13][CH2:14][CH3:15])[cH:3][cH:4][c:5]([OH:8])[cH:6][n:7]1

Participants

8

Reactant 7

HCID 175Acetate2×HCID 6228DimethylformamideHCID 8471TriethylamineHCID 8821Ethyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 27628652-Bromo-5-hydroxypyridine

Product 1

HCID 67270386Ethyl 3-(5-hydroxypyridin-2-yl)prop-2-enoate

Sources & evidence

ORD record
ord-70ae0b1ceccc4cc7ad42931942561ef5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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