Citric Acid → 4-Bromo-5-chlorothiophene-2-carbaldehyde

HRID 2340283Notes

Reaction equation

HRID 2340283 reaction equation
[Br:1][c:2]1[c:3]([Cl:7])[s:4][cH:5][cH:6]1.[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:39][CH2:40][O:41][C:42](=[O:43])[CH3:44].[CH:8]([N-:9][CH:10]([CH3:11])[CH3:12])([CH3:13])[CH3:14].[Li+:15].[O:16]=[CH:17][N:18]([CH3:19])[CH3:20].[OH:21][C:22]([CH2:23][C:24]([C:25](=[O:26])[OH:27])([CH2:28][C:29](=[O:30])[OH:31])[OH:32])=[O:33]>>[Br:1][c:2]1[c:3]([Cl:7])[s:4][c:5]([CH:17]=[O:16])[cH:6]1

Participants

8

Reactant 7

HCID 311Citric AcidHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 28486Lithium ionHCID 27245593-Bromo-2-chlorothiopheneHCID 5062348Diisopropylamide

Product 1

HCID 216784984-Bromo-5-chlorothiophene-2-carbaldehyde

Sources & evidence

ORD record
ord-1a0d222a5ff34e028ca21204f735fba2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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