Trifluoroacetic acid → HCID 178484467, compound

HRID 234152Notes

Reaction equation

HRID 234152 reaction equation
[C:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]([N:12]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]([O:27]C(C)(C)C)=[O:26])=[C:19]([O:32][CH2:33][C:34]([O:36]C(C)(C)C)=[O:35])[CH:18]=2)=[O:16])[CH3:13])=[O:11])[CH2:6][CH2:5]1)(=[NH:3])[NH2:2].[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].C(OC(C)C)(C)C>C1(OC)C=CC=CC=1>[F:41][C:42]([F:47])([F:46])[C:43]([OH:45])=[O:44].[C:1]([C@H:4]1[CH2:9][CH2:8][C@H:7]([C:10]([N:12]([CH2:14][C:15]([C:17]2[CH:22]=[CH:21][C:20]([O:23][CH2:24][C:25]([OH:27])=[O:26])=[C:19]([O:32][CH2:33][C:34]([OH:36])=[O:35])[CH:18]=2)=[O:16])[CH3:13])=[O:11])[CH2:6][CH2:5]1)(=[NH:2])[NH2:3]

Participants

5

Reactant 3

HCID 6422Trifluoroacetic acidHCID 7914Diisopropyl EtherHCID 178484466HCID 178484466, compound

Product 1

HCID 178484467HCID 178484467, compound

Reagents, catalysts & solvents 1

HCID 7519AnisoleSolvent

Procedure

To the solution of the compound prepared in (d) (50 mg, 0.089 mmole) in anisole was added trifluoroacetic acid under ice-cooling. The mixture was stirred for 5 hours, during which the temperature of the mixture was left rising up to room temperature. After isopropyl ether was added to the reaction mixture, solids deposited were collected to give 31 mg of the title compound as the colorless solid (yield, 62%).

Workup

  1. temperaturecooling
  2. waitwas left
  3. customrising up to room temperature
  4. customdeposited were collected

Sources & evidence

ORD record
ord-790f784a638c48bca17cd42faf1db180
Source dataset
uspto-grants-1997_01
Patent number
US05594004

Reaction notes

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