Triethylamine → 2-Chloro-4-[2-(4-fluorophenyl)ethynyl]pyrimidine

HRID 2342318Notes

Reaction equation

HRID 2342318 reaction equation
[C:9](#[CH:10])[c:11]1[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]1.[CH3:62][CH2:63][N:64]([CH2:65][CH3:66])[CH2:67][CH3:68].[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([Cl:8])[n:7]1.[Cu:59]([I:60])[I:61].[Pd:18]([Cl:19])[Cl:20].[c:21]1([P:22]([c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[c:29]2[cH:30][cH:31][cH:32][cH:33][cH:34]2)[cH:35][cH:36][cH:37][cH:38][cH:39]1.[c:40]1([P:41]([c:42]2[cH:43][cH:44][cH:45][cH:46][cH:47]2)[c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)[cH:54][cH:55][cH:56][cH:57][cH:58]1>>[Cl:1][c:2]1[n:3][cH:4][cH:5][c:6]([C:10]#[C:9][c:11]2[cH:12][cH:13][c:14]([F:17])[cH:15][cH:16]2)[n:7]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 775312,4-DichloropyrimidineHCID 83717Copper iodideHCID 5226271-Ethynyl-4-fluorobenzene

Product 1

HCID 121652312-Chloro-4-[2-(4-fluorophenyl)ethynyl]pyrimidine

Sources & evidence

ORD record
ord-a1ded0fad19b48708a6357b80eae628b
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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