Hydrochloric Acid → Pyrimidine-5-carboxylic acid [2-(2,6-dioxopiperidin-3-YL)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]amide

HRID 2344146Notes

Reaction equation

HRID 2344146 reaction equation
[C:10]([n:11]1[cH:12][cH:13][n:14][cH:15]1)([n:16]1[cH:17][cH:18][n:19][cH:20]1)=[O:21].[CH3:44][CH2:45][N:46]([CH2:47][CH3:48])[CH2:49][CH3:50].[ClH:22].[NH2:23][CH2:24][c:25]1[c:26]2[c:30]([cH:31][cH:32][cH:33]1)[C:29](=[O:34])[N:28]([CH:35]1[C:36](=[O:42])[NH:37][C:38](=[O:41])[CH2:39][CH2:40]1)[C:27]2=[O:43].[O:51]=[CH:52][N:53]([CH3:54])[CH3:55].[n:1]1[cH:2][n:3][cH:4][c:5]([C:7](=[O:8])[OH:9])[cH:6]1>>[n:1]1[cH:2][n:3][cH:4][c:5]([C:7](=[O:9])[NH:23][CH2:24][c:25]2[c:26]3[c:30]([cH:31][cH:32][cH:33]2)[C:29](=[O:34])[N:28]([CH:35]2[C:36](=[O:42])[NH:37][C:38](=[O:41])[CH2:39][CH2:40]2)[C:27]3=[O:43])[cH:6]1

Participants

7

Reactant 6

HCID 313Hydrochloric AcidHCID 6228DimethylformamideHCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 78346Pyrimidine-5-carboxylic acidHCID 219885264-(Aminomethyl)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione

Product 1

HCID 58827293Pyrimidine-5-carboxylic acid [2-(2,6-dioxopiperidin-3-YL)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-ylmethyl]amide

Sources & evidence

ORD record
ord-957106ccad454a07a410046e62e8fadd
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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