Diethylamine → 1-(4-Trimethylsilylethynyl-phenyl)-2,2-dimethylpropan-1-one

HRID 2345109Notes

Reaction equation

HRID 2345109 reaction equation
[Br:7][c:8]1[cH:9][cH:10][c:11]([C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:12][cH:13]1.[CH2:20]([NH:21][CH2:22][CH3:23])[CH3:24].[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[CH:6].[Cu:66][I:67].[Pd:25]([Cl:26])[Cl:27].[c:28]1([P:29]([c:30]2[cH:31][cH:32][cH:33][cH:34][cH:35]2)[c:36]2[cH:37][cH:38][cH:39][cH:40][cH:41]2)[cH:42][cH:43][cH:44][cH:45][cH:46]1.[c:47]1([P:48]([c:49]2[cH:50][cH:51][cH:52][cH:53][cH:54]2)[c:55]2[cH:56][cH:57][cH:58][cH:59][cH:60]2)[cH:61][cH:62][cH:63][cH:64][cH:65]1>>[CH3:1][Si:2]([CH3:3])([CH3:4])[C:5]#[C:6][c:8]1[cH:9][cH:10][c:11]([C:14]([C:15]([CH3:16])([CH3:17])[CH3:18])=[O:19])[cH:12][cH:13]1

Participants

7

Reactant 6

HCID 8021DiethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 66111TrimethylsilylacetyleneHCID 128120801-(4-Bromophenyl)-2,2-dimethylpropan-1-one

Product 1

HCID 202368631-(4-Trimethylsilylethynyl-phenyl)-2,2-dimethylpropan-1-one

Sources & evidence

ORD record
ord-59bfb0c6e8a2444c9278b5987ee3cc60
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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