Hydrochloric Acid → 4'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

HRID 2350475Notes

Reaction equation

HRID 2350475 reaction equation
[C:43]([CH3:44])([CH3:45])([CH3:46])[Si:47]([CH3:48])([CH3:49])[Cl:50].[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:36][CH2:37][N:38]([CH2:39][CH3:40])[CH2:41][CH3:42].[CH3:61][c:62]1[cH:63][cH:64][cH:65][cH:66][cH:67]1.[ClH:1].[N:2]1([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[c:19]3[c:20]4[c:21]([s:22][c:23]3-[c:24]3[cH:25][cH:26][c:27]([OH:30])[cH:28][cH:29]3)[cH:31][c:32]([OH:35])[cH:33][cH:34]4)[cH:15][cH:16]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1.[O:56]=[CH:57][N:58]([CH3:59])[CH3:60]>>[N:2]1([CH2:8][CH2:9][O:10][c:11]2[cH:12][cH:13][c:14]([C:17](=[O:18])[c:19]3[c:20]4[c:21]([s:22][c:23]3-[c:24]3[cH:25][cH:26][c:27]([O:30][Si:47]([C:43]([CH3:44])([CH3:45])[CH3:46])([CH3:48])[CH3:49])[cH:28][cH:29]3)[cH:31][c:32]([OH:35])[cH:33][cH:34]4)[cH:15][cH:16]2)[CH2:3][CH2:4][CH2:5][CH2:6][CH2:7]1

Participants

8

Reactant 7

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 5035RaloxifeneHCID 6228DimethylformamideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 28928tert-Butyldimethylsilyl chloride

Product 1

HCID 106034474'-tert-Butyldimethylsilyl-6-hydroxy Raloxifene

Sources & evidence

ORD record
ord-fa88c6bbd0ec4638a07806f5e751f613
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…