Potassium Carbonate → 6-Bromo-N-(2-(dimethylamino)ethyl)phthalazin-1-amine

HRID 2357604Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8](Cl)=[N:7][N:6]=[CH:5]2.C(=O)([O-])[O-].[K+].[K+].[CH3:19][N:20]([CH3:24])[CH2:21][CH2:22][NH2:23]>CN(C)C=O.CCOC(C)=O>[Br:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:8]([NH:23][CH2:22][CH2:21][N:20]([CH3:24])[CH3:19])=[N:7][N:6]=[CH:5]2

Participants

Conditions

Temperature: 80 °C

Procedure

6-Bromo-1-chlorophthalazine (0.22 g, 0.91 mmol) was dissolved in N,N-dimethylformamide (3 mL) and potassium carbonate (0.25 g, 1.81 mmol) and N1,N1-dimethylethane-1,2-diamine (0.20 mL, 1.81 mmol) was added. The reaction mixture was heated to 80° C. for 5 h, cooled to ambient temperature and stirred for 16 h. The reaction mixture was diluted with 20 mL of EtOAc, added to an addition funnel and partitioned with sodium bicarbonate (saturated, aqueous). The organic layer was washed 3x with 20 mL of sodium bicarbonate (saturated, aqueous) and once with aqueous brine, separated, dried over sodium sulfate, and concentrated via rotovap to give crude product. The crude was purified by chromatography to obtain the title compound. Found MS (ES+): 295(M+H)+.

Workup

temperaturecooled to ambient temperature
additionadded to an addition funnel
custompartitioned with sodium bicarbonate (saturated, aqueous)
washThe organic layer was washed 3x with 20 mL of sodium bicarbonate (saturated, aqueous)
customonce with aqueous brine, separated
dry with materialdried over sodium sulfate
concentrationconcentrated via rotovap
customto give crude product
customThe crude was purified by chromatography

Sources & evidence

ORD record: ord-d35ea5c11b8b40a495f52c0c093b7cd2
Source dataset: uspto-grants-2010_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07759337B2

Reaction notes

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