Hydrochloric Acid → HCID 59625897, compound

HRID 2362137Notes

Reaction equation

HRID 2362137 reaction equation
[Li+].[OH-].F[C:4]1[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[CH:11]=[CH:10][C:5]=1[C:6]([O:8]C)=O.[SH:18][CH2:19][C:20]([O:22][CH3:23])=[O:21].Cl>CN(C=O)C.O>[OH:8][C:6]1[C:5]2[CH:10]=[CH:11][C:12]([C:14]([F:17])([F:16])[F:15])=[CH:13][C:4]=2[S:18][C:19]=1[C:20]([O:22][CH3:23])=[O:21]

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 3939Lithium HydroxideHCID 16907Methyl ThioglycolateHCID 18925690HCID 18925690, compound

Product 1

HCID 59625897HCID 59625897, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Conditions

Temperature
0 °C

Procedure

LiOH (4.5 mmol, 0.11 g) was added to a solution of methyl 2-fluoro-4-trifluoromethylbenzoate 68a (2.25 mmol, 0.50 g) and methyl 2-mercaptoacetate 67d (2.25 mmol, 0.21 mL) in DMF (3 mL) at 0° C. The mixture was stirred at 0° C. for 30 min and then warmed to room temperature and stirred for 1 h. Water was added and the resulting solution was acidified with 1N aqueous HCl. The precipitates were filtered, washed with water, and dried to give compound 68b.

Workup

  1. temperaturewarmed to room temperature
  2. stirringstirred for 1 h
  3. filtrationThe precipitates were filtered
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-119aa4727d6a42238e6f7ce7f6e3fd43
Source dataset
uspto-grants-2014_04
Patent number
US08691805B2

Reaction notes

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