Hydrochloric Acid → HCID 178510543, compound

HRID 2362813Notes

Reaction equation

HRID 2362813 reaction equation
[OH:1][CH2:2][CH2:3][O:4][NH:5][C:6]1[C:11]([C:12]#[N:13])=[C:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][OH:23])=[CH:16][CH:15]=2)[C:9]([C:24]#[N:25])=[C:8]([S:26]C2C=CC=CC=2)[N:7]=1.[S-2].[Na+].[Na+].Cl>CN(C=O)C>[OH:1][CH2:2][CH2:3][O:4][NH:5][C:6]1[C:11]([C:12]#[N:13])=[C:10]([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH2:21][CH2:22][OH:23])=[CH:16][CH:15]=2)[C:9]([C:24]#[N:25])=[C:8]([SH:26])[N:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14804Sodium SulfideHCID 57452402HCID 57452402, compound

Product 1

HCID 178510543HCID 178510543, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

0.30 g (0.70 mmol) of the compound from Example 31A is dissolved in 2 ml of DMF, and 0.19 g (2.43 mmol) of sodium sulphide is added. The mixture is stirred at 80° C. for 2 h and then at RT for 12 h. 1N hydrochloric acid (10 ml) is then added, and the precipitate is filtered off.

Workup

  1. waitat RT for 12 h
  2. filtrationthe precipitate is filtered off

Sources & evidence

ORD record
ord-bc8f7d9f1b3c4fceaf8d71579fe2935d
Source dataset
uspto-grants-2014_04
Patent number
US08691850B2

Reaction notes

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