Hydrochloric Acid → HCID 66691239, compound

The mixture of 5-chloro-3-ethoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (310 mg, 1 mmol), NaOH (40 mg, 1 mmol) and CTAB (5 mg, 0.05 mmol) in H2O (2 mL) and THF (10 mL) was stirred for 0.5 h at room temperature. After dropwise addition of nitromethane (0.2 mL, 2 mmol), the reaction mixture was stirred at room temperature for 3 h. Then the cyclization was afforded by adding the diluted aqueous HCl solution (2 N) to pH=2 and then extracted with EtOAc (3×30 mL). The combined organic layers were washed with brine (25 mL), dried over anhydrous Na2SO4 and concentrated to dryness. The residue was purified by prep-HPLC to give the compound (100 mg, yield: 56%). 1H NMR (400 MHz, DMSO-d6) δ 9.20 (s, 1H), 7.22 (s, 1H), 6.96 (s, 1H), 5.69-5.72 (m, 1H), 5.30-5.34 (m, 1H), 4.61-4.67 (m, 1H), 4.10-4.15 (m, 2H), 1.31-1.34 (m, 3H);

1. stirringthe reaction mixture was stirred at room temperature for 3 h
2. customThen the cyclization was afforded
3. extractionextracted with EtOAc (3×30 mL)
4. washThe combined organic layers were washed with brine (25 mL)
5. dry with materialdried over anhydrous Na2SO4
6. concentrationconcentrated to dryness
7. customThe residue was purified by prep-HPLC

ORD record

ord-2f320b4be19a476e8f43873721209b5b

Source dataset

uspto-grants-2014_04

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US08703742B2