Phenylacetic Acid → HCID 58611841, compound

HRID 2375205Notes

Reaction equation

HRID 2375205 reaction equation
C1(C)C=CC(S(O)(=O)=O)=CC=1.[C:12]1([CH2:18][C:19]([OH:21])=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[O:22]1[CH:27]=[CH:26][CH2:25][CH2:24][CH2:23]1.C(N(CC)CC)C>ClCCl>[C:12]1([CH2:18][C:19]([O:21][CH:23]2[CH2:24][CH2:25][CH2:26][CH2:27][O:22]2)=[O:20])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1

Participants

6

Reactant 4

HCID 999Phenylacetic AcidHCID 6101p-Toluenesulfonic acidHCID 80803,4-dihydro-2H-pyranHCID 8471Triethylamine

Product 1

HCID 58611841HCID 58611841, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a saturated solution of anhydrous p-toluenesulphonic acid in dry dichloromethane (25 ml), phenylacetic acid (E4) (0.581 g, 4.26 mmol) and 3,4-dihydro-2H-pyran (3 ml, 32.9 mmol) were successively added, and the resultant solution was stirred for 1 hour at room temperature. To the reaction mixture, triethylamine (1 ml, 7.2 mmol) was added, and the volatiles were evaporated. The crude title compound was obtained and was immediately utilized in the next step of the synthesis.

Workup

  1. customthe volatiles were evaporated

Sources & evidence

ORD record
ord-158d3a2127d54cae960a43a7a7865527
Source dataset
uspto-grants-2008_12
Patent number
US07465719B2

Reaction notes

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