Nitrogen → HCID 58709908, compound

HRID 2375887Notes

Reaction equation

N#N.I[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[CH:6][C:5]=1[O:13][CH3:14].[S:15]1[CH:19]=[CH:18][N:17]=[CH:16]1.C([O-])(=O)C.[K+]>CN(C=O)C>[CH3:14][O:13][C:5]1[CH:6]=[CH:7][C:8]([N+:10]([O-:12])=[O:11])=[CH:9][C:4]=1[C:19]1[S:15][CH:16]=[N:17][CH:18]=1

Participants

Conditions

Temperature: 100 °C

Procedure

N2 was bubbled through a solution of 2-iodo-4-nitroanisole (2.8 g, 10.0 mmol), thiazole (2.55 g, 30.0 mmol), potassium acetate (1.47 g, 15.0 mmol), and tetrakis(triphenyl phosphine)palladium(0) (0.81 g, 0.70 mmol) in DMF (15 mL) for 10 min. The mixture was then heated to 100° C. and stirred overnight. Solvent was removed under reduced pressure, and the residue was purified by silica gel chromatography (dichloromethane:MeOH=96:4) to afford the title compound. 1H-NMR (CDCl3, 400 MHz): δ=4.08 (s, 3H), 7.09 (d, J=9.2 Hz, 1H), 8.25 (dd, J=2.8, 9.2 Hz, 1H), 8.37 (s, 1H), 8.54 (d, J=3.2 Hz, 1H), 8.88 (s, 1H). MS (ES+): m/z 237.13 [MH+]. HPLC: tR=3.07 min (ZQ2000, polar—5 min).

Workup

customSolvent was removed under reduced pressure
customthe residue was purified by silica gel chromatography (dichloromethane:MeOH=96:4)

Sources & evidence

ORD record: ord-c06c345969d94310866c6af8c64c9422
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07465726B2

Reaction notes

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