Sodium hydride → HCID 21313321, compound

HRID 2397502Notes

Reaction equation

HRID 2397502 reaction equation
[CH:1]1([CH2:7][CH2:8][CH2:9][CH:10]2[CH2:15][CH2:14][CH2:13][CH2:12][N:11]2[CH2:16][CH2:17][C:18]2[C:26]3[C:21](=[CH:22][CH:23]=[C:24]([O:27][CH3:28])[CH:25]=3)[NH:20][C:19]=2[CH3:29])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[H-].[Na+].[Na].F[C:34]1[CH:42]=[CH:41][C:37]([C:38](Cl)=[O:39])=[CH:36][CH:35]=1>CN(C=O)C>[C:38]([N:20]1[C:21]2[C:26](=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[C:18]([CH2:17][CH2:16][N:11]2[CH2:12][CH2:13][CH2:14][CH2:15][CH:10]2[CH2:9][CH2:8][CH2:7][CH:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[C:19]1[CH3:29])(=[O:39])[C:37]1[CH:41]=[CH:42][CH:34]=[CH:35][CH:36]=1

Participants

6

Reactant 4

HCID 24758Sodium hydrideHCID 678794-Fluorobenzoyl chlorideHCID 5360545SodiumHCID 21313375HCID 21313375, compound

Product 1

HCID 21313321HCID 21313321, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

Reaction of 3-{2-[2-(3-cyclohexylpropyl)piperidino]ethyl}-5-methoxy-2-methylindole with a mineral oil dispersion of sodium hydride in DMF and reaction of the resulting sodium salt with 4-fluorobenzoyl chloride affords 1-benzoyl-3-{2-[2-(3-cyclohexylpropyl)piperidino]ethyl}-5-methoxy-2-methylindole.

Sources & evidence

ORD record
ord-733a0d4157d2420fab643f33a55e52b3
Source dataset
uspto-grants-1977_05
Patent number
US04021431

Reaction notes

Loading…