Guaiacol → 2-(2-Methoxyphenoxy)-1-phenylethanone

HRID 2397881Notes

Reaction equation

HRID 2397881 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9].C(=O)([O-])[O-].[K+].[K+].Br[CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]>CC(C)=O>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[O:9][CH2:17][C:18]([C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:19]

Participants

5

Reactant 3

HCID 460GuaiacolHCID 6259Phenacyl bromideHCID 11430Potassium Carbonate

Product 1

HCID 3552752-(2-Methoxyphenoxy)-1-phenylethanone

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 1 mole of 2-methoxyphenol and 1 mole of potassium carbonate in acetone is heated at reflux while adding 1 mole of alpha-bromoacetophenone. The mixture is refluxed for several hours to provide alpha-(2-methoxyphenoxy)acetophenone.

Workup

  1. temperatureis heated
  2. temperatureat reflux
  3. temperatureThe mixture is refluxed for several hours

Sources & evidence

ORD record
ord-636de395bb4a48a6a847015aefffe9e1
Source dataset
uspto-grants-1977_05
Patent number
US04022908

Reaction notes

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